Shanghai Chemtron Biotech Co.Ltd.

Application of PSA

Prostate cancer is one of the most common tumors in men. The disease is common in older men over 60. Genetic factors, family history, nutritional factors (such as vitamin D deficiency or high calcium intake), obesity and a high-fat diet are all risk factors for prostate cancer. Prostate cancer has a long incubation period, high disability rate and mortality. Due to the introduction and renewal of diagnostic techniques such as PSA testing, as well as the early intervention treatment of diseases, the mortality rate of prostate cancer is gradually decreasing. The latest figures show that the rate of early diagnosis of prostate cancer by PSA has increased 1.6 times and the mortality rate has decreased by 21 percent.

PSA is a proteolytic enzyme produced by prostate epithelial cells. It exists in the cytoplasm of prostate epithelial cells and is normally secreted into prostatic fluid or semen. The majority of PSA in serum comes from prostate gland, which is organ specific. The data showed that PSA and prostate stage are positively correlated, and the higher PSA level is, the higher the probability of prostate cancer is. Therefore, PSA is used as the most sensitive marker of prostate cancer, and is widely used in the early diagnosis, treatment response monitoring and prognosis judgment of prostate cancer. At the same time, PSA combined with rectal fingerprinting can also be used for prostate screening in high-risk groups (family history and age > 50 years old). It is worth noting that PSA level is positively correlated with age. The older the PSA is, the higher the PSA level is, and each age group has its own reference value. Only on this basis can the comparison be more accurate. PSA is a prostate-specific antigen, not a specific antigen for prostate cancer. When prostatitis and benign prostatic hyperplasia occur, PSA can also be increased, so other benign diseases should be excluded. To eliminate benign prostate diseases, simultaneous fPSA testing may be considered. PSA is divided into Tpsa, cPSA, fPSA and Tpsa.Only detecingt fPSA in serum makes little sense to the diagnosis of prostate cancer, but, fPSA/tPSA ratio can be used to identify prostate cancer and benign prostatic hyperplasia: when less than 10 ng/ml (tPSA, fPSA/tPSA can increase the diagnosis of prostate cancer specific degrees, the ratio is usually lower than normal and prostate hyperplasia of prostate cancer patients (usually > 0.25), and fPSA/tPSA is less than 0.16 is highly suggestie of prostate cancer, must further clinical diagnosis.

However, since serum PSA test has been used for prostate cancer screening for more than 20 years, it is controversial whether to carry out universal prostate cancer screening. The data showed that PSA test could not distinguish the aggressive or slow progression of prostate cancer due to the limitation of sensitivity and specificity of PSA test. For slow-moving prostate cancer, screening is unnecessary and even harmful because it can lead to unnecessary invasive biopsies and overtreatment. Therefore, it is necessary to apply PSA test extensively to prostate cancer screening only for high-risk groups (family history, age 55 to 69).

It is worth noting that PSA, as an organ-specific antigen, has long been used only as a screening indicator for prostate cancer, and is only used for men, but not for women. However, more and more studies show that serum PSA test can also be applied to the screening and diagnosis of some clinical diseases in women. The female serum PSA mainly has the mammary gland secretion, the normal situation can see the low level secretion. Benign breast disease and breast cancer patients is significantly higher, PSA PSA levels and molecular forms can be used to distinguish between Ⅰ and Ⅱ breast cyst. Therefore, women can also add PSA and fPSA tests when testing for breast diseases.

Chemtron biotech psa rapid test kits is of high quality. Learn more about the psa rapid test kits from chemtron biotech.
Related News
  • Hepatitis C Core Antigen Detection Kit

    Hepatitis C Core Antigen Detection Kit

    July 26, 2018The core of the HCV test reagent was made from the gene reconstituted HCV - cAg and the HCV - cAg, the anti-hcv - cAg, the HCV - cAg, the HCV, the antivirus, the monoclonal antibody, which is made up ...view
  • Fluorescent Immunochromatographic Technique

    Fluorescent Immunochromatographic Technique

    August 8, 2018Fluorescence immunochromatography is a new membrane detection technology based on antigen - antibody - specific immune response. The technique uses a strip of fibrous tomography material with a fixed ...view
  • Urinary Microalbumin and Nephropathy

    Urinary Microalbumin and Nephropathy

    August 8, 2018Proteinuria is the main clinical symptom of nephropathy, and the detection of microalbumin is of great clinical value in determining the degree of disease and prognosis. Because the main symptom of ne...view
  • Ovarian Examination

    Ovarian Examination

    July 26, 2018Ovarian examination is a functional examination of the ovaries to understand ovarian function, preventing and treating ovarian disease in time.The basal body temperature is constant. Examination of va...view
  • Interpretation of FSH

    Interpretation of FSH

    August 8, 2018FSH is a hormone secreted by basophils in the anterior pituitary gland. It is composed of glycoproteins and its main function is to promote follicular maturation. Human follicular stimulating hormone ...view
  • Menopausal Clinical Manifestations

    Menopausal Clinical Manifestations

    July 26, 2018The most typical symptoms of perimenopausal syndrome are hot flashes, mostly happens between 45 and 55 years old. And most women can have symptoms of varying severity. Some people begin to show sympto...view
  • TEL:+86-21-68129666
  • FAX:+86-21-68129222
  • EMAIL:international@chemtronbio.com
  • ADDRESS:No.518, Qingdai Rd., International Medical Park, Pudong, 201318, Shanghai, P.R.China