Shanghai Chemtron Biotech Co.Ltd.

Perimenopausal Syndrome

Perimenopausal syndrome, also known as menopause syndrome (MPS), refers to a series of disorders of autonomic nervous system mainly caused by sexual hormone fluctuation or reduction before and after menopause, accompanied by neuropsychological symptoms. Menopause can be divided into natural menopause and artificial menopause. Natural menopause refers to the exhaustion of follicles in the ovaries, or the loss of the remaining follicles in response to gonadotropin, the follicles no longer develop and secrete estrogen, cannot stimulate the growth of the endometrium, leading to menopause. Artificial menopause refers to surgical removal of bilateral ovaries or other methods to stop ovarian function, such as radiation therapy and chemotherapy. If the uterus is removed alone and one or both ovaries are retained, it is not considered as artificial menopause.

Etiology
The underlying cause of perimenopausal syndrome is ovarian failure due to physiological or pathological or surgical reasons. Once ovarian function is depleted or is excised and destroyed, the ovary secretes less estrogen. The female body has more than 400 kinds of estrogen receptors, which are distributed in almost all the tissues and organs of the female body. They are controlled by estrogen.

1. Neurotransmitter
Hypothalamus neurotransmitter opioids (EOP), adrenalin (NE), dopamine (DA) and other neurotransmitters are significantly associated with hot flashes. Serotonin (5-ht) can regulate endocrine, cardiovascular, emotional and sexual life.

2. Genetic factors
Twins with perimenopausal syndrome start at exactly the same time, and their symptoms and duration are very similar. Individual personality characteristics, neural types, cultural level, occupation, social and family background are related to the onset and severity of perimenopausal syndrome. It is suggested that the occurrence of this disease may be related to higher nervous activity.

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