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The Importance of Cardiac Troponin I

CTnI will be elevated in the blood of patients with myocarditis. Smith et al. studied 53 patients with myocarditis and found that the plasma cTnI level of 18 patients is significantly increased, while only 3 patients had increased ck-mb level. Therefore, cTnI is more sensitive to myocardial injury than ck-mb, and can be a specific and sensitive indicator of serum in myocarditis.

Stromal cardiac troponin I is also important in the clinical treatment and prognosis of heart disease
Vecchia et al. continuously measured the plasma cTnI levels of 26 hospitalized or outpatient patients with mental failure by immunofluorescence, and found that 6 patients had significantly increased cTnI levels, among which 3 died, 3 patients became normal after treatment, and 20 patients with normal plasma cTnI maintained normal new functions. The measurement of cTnI in serum of unstable angina patients is helpful to predict the occurrence of myocardial infarction. For patients with acute coronary syndromes, plasma cTnI levels can provide prognostic information and early identification of patients at risk of death. Serum cTnI can be used to determine the degree of myocardial injury and prognosis in patients with supraventricular tachycardia treated by electrocardiography.

The clinical diagnosis of myocardial infarction and mild coronary ischemia syndrome is difficult, especially in emergencies, when the patient's symptoms are not typical or the electrocardiogram diagnosis is not clear. Biochemical detection of myocardial specific cTnI provides a new diagnostic basis. Application of cTnI determination can be detected clinically asymptomatic myocardial ischemia patients, improve the diagnostic positive rate of myocardial ischemia, such as the marathon athletes, skeletal muscle damage, muscle pathological changes etc. So some people think that the plasma cTnI on myocardial damage 100% sensitive and specific which is a golden diagnosis of myocardial injury index. The reasons are the following:

A. The only type of cTnI is found in cardiac tissue.
B. Circulating cTnI is not expressed in skeletal muscle injury;
C. When measuring cTnI and skeletal muscle TnI with antibodies, there is no crossover reaction.
D. Ck-mb in patients with long-term endurance exercise or kidney diseaseis increased, but cTnI is not increased.
E. Correspondingly increased cTnI is closely related to myocardial injury prediction.
F. The cTnI concentration in the hollow heart is 13 times higher than that of ck-mb, so cTnI is more sensitive than ck-mb.
G. Tool is not affected by hypothyroidism.

Therefore, the detection of cTnI is sensitive and specific to heart diseases, and has a wide application prospect in the diagnosis of cardiovascular diseases.

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