Shanghai Chemtron Biotech Co.Ltd.

The Importance of Cardiac Troponin I

CTnI will be elevated in the blood of patients with myocarditis. Smith et al. studied 53 patients with myocarditis and found that the plasma cTnI level of 18 patients is significantly increased, while only 3 patients had increased ck-mb level. Therefore, cTnI is more sensitive to myocardial injury than ck-mb, and can be a specific and sensitive indicator of serum in myocarditis.

Stromal cardiac troponin I is also important in the clinical treatment and prognosis of heart disease
Vecchia et al. continuously measured the plasma cTnI levels of 26 hospitalized or outpatient patients with mental failure by immunofluorescence, and found that 6 patients had significantly increased cTnI levels, among which 3 died, 3 patients became normal after treatment, and 20 patients with normal plasma cTnI maintained normal new functions. The measurement of cTnI in serum of unstable angina patients is helpful to predict the occurrence of myocardial infarction. For patients with acute coronary syndromes, plasma cTnI levels can provide prognostic information and early identification of patients at risk of death. Serum cTnI can be used to determine the degree of myocardial injury and prognosis in patients with supraventricular tachycardia treated by electrocardiography.

The clinical diagnosis of myocardial infarction and mild coronary ischemia syndrome is difficult, especially in emergencies, when the patient's symptoms are not typical or the electrocardiogram diagnosis is not clear. Biochemical detection of myocardial specific cTnI provides a new diagnostic basis. Application of cTnI determination can be detected clinically asymptomatic myocardial ischemia patients, improve the diagnostic positive rate of myocardial ischemia, such as the marathon athletes, skeletal muscle damage, muscle pathological changes etc. So some people think that the plasma cTnI on myocardial damage 100% sensitive and specific which is a golden diagnosis of myocardial injury index. The reasons are the following:

A. The only type of cTnI is found in cardiac tissue.
B. Circulating cTnI is not expressed in skeletal muscle injury;
C. When measuring cTnI and skeletal muscle TnI with antibodies, there is no crossover reaction.
D. Ck-mb in patients with long-term endurance exercise or kidney diseaseis increased, but cTnI is not increased.
E. Correspondingly increased cTnI is closely related to myocardial injury prediction.
F. The cTnI concentration in the hollow heart is 13 times higher than that of ck-mb, so cTnI is more sensitive than ck-mb.
G. Tool is not affected by hypothyroidism.

Therefore, the detection of cTnI is sensitive and specific to heart diseases, and has a wide application prospect in the diagnosis of cardiovascular diseases.

Chemtron biotech
troponin i rapid test kit is of high quality. Learn more about the troponin i rapid test kit from chemtron biotech.
Related News
  • Prostate Specific Antigen Examination

    Prostate Specific Antigen Examination

    August 8, 2018Prospecific antigen (PSA) is a single-stranded glycoprotein with 237 amino acid residues produced by proepithelial cell plasma vesicles, with a molecular weight of about 34kD. It belongs to serine pro...view
  • Urinary Microalbumin and Cardiovascular Disease

    Urinary Microalbumin and Cardiovascular Disease

    August 8, 2018Through the study of diabetic patients, it was found that the incidence of cardiovascular diseases in MUA positive patients was higher, the onset time was earlier, and the degree of lesions was more s...view
  • Menopausal Clinical Manifestations

    Menopausal Clinical Manifestations

    July 26, 2018The most typical symptoms of perimenopausal syndrome are hot flashes, mostly happens between 45 and 55 years old. And most women can have symptoms of varying severity. Some people begin to show sympto...view
  • Ovarian Function Test Paper

    Ovarian Function Test Paper

    July 26, 2018Ovary is an important organ of female reproductive system, its main function is to produce and excrete eggs and secrete hormones. Not only in the fertility play a decisive role, but also let women fro...view
  • Cardiac troponin I and Cardiac Diseases

    Cardiac troponin I and Cardiac Diseases

    August 8, 2018Troponin (Tn) is a regulatory protein related to myocardial and skeletal muscle contraction. It consists of three subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). TnI can also be div...view
  • Method for Rapid Strep Test Kit

    Method for Rapid Strep Test Kit

    April 9, 2019Method for rapid strep test kit (ELISA indirect method)(1) Loading: Take the pre-coated enzyme-linked plate coated with recombinant syphilis-specific antigen. Each control was provided with a blank co...view
  • TEL:+86-21-68129666
  • FAX:+86-21-68129222
  • EMAIL:international@chemtronbio.com
  • ADDRESS:No.518, Qingdai Rd., International Medical Park, Pudong, 201318, Shanghai, P.R.China