Through the study of diabetic patients, it was found that the incidence of cardiovascular diseases in MUA positive patients was higher, the onset time was earlier, and the degree of lesions was more serious. Epidemiological studies have shown that the incidence and mortality of cardiovascular diseases are associated with increased MUA. A study by American researchers looked at 194 patients with cardiovascular disease and 189 healthy people and compared their MUA changes. UAE:0-30mg/24h was used as the standard MUA in healthy people, and MUA in patients was 30-300mg/24h. A paired study of age, sex, and the incidence of cardiovascular disease confirmed significant differences between healthy people and patients. In addition, other risk factors include systolic blood pressure, diastolic blood pressure, serum cholesterol, vascular endothelial growth factor (VAGF), blood glucose, and body weight, all of which are significantly correlated with the incidence of cardiovascular diseases. Another large retrospective study that assessed the risk factors associated with cardiovascular events from 1990 to 2002 showed a significant increase in deaths from cardiovascular events in people with MUA positivity, especially in those with diabetes and hypertension. The death rate from cardiovascular events in mua-positive patients was 2-8 times higher than in mua-negative patients. The results confirm that MUA is not only associated with mortality from diabetes and hypertension, but also with mortality from cardiovascular events. Therefore, it is believed that sufficient attention should be paid to MUA positive patients in clinical practice to strengthen the treatment of primary diseases. Some scholars believe that MUA has the same clinical significance in predicting the risk factors of cardiovascular diseases as hyperlipidemia, hypercysteine, increased c-reactive protein, infection and increased fibrinogen.
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