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Urinary Microalbumin and Diabetes Mellitus

Diabetes deaths are mostly due to diabetes complications. The increase of MUA in diabetic patients has been confirmed by a large number of clinical studies. In the past decade, it has been clearly recognized that MUA positive is an early sign of vascular injury and is closely related to the prognosis of type 1 and type 2 diabetes. That is to say, MUA positive diabetes mortality is significantly higher than the MUA negative people. Studies have shown that MUA predates diabetes mellitus with hypertension, cardiovascular disease and neuropathy. The increase of MUA is closely related to the changes of insulin resistance and glucose tolerance. Therefore, it is considered that the increase of MUA in diabetic patients is an early indicator of the occurrence of diabetes complications, which has important reference value to predict the occurrence of diabetes complications. MUA continues to increase in patients, eventually leading to diabetic nephropathy. The prognosis of MUA patients with persistent positive sex is poor. Some experimental studies have also shown that MUA positive in diabetics is closely related to cardiovascular disease. So MUA positive people are more likely to have cardiovascular disease. Therefore, MUA positive is not only a risk factor for renal vascular injury, but also a risk factor for diabetes mellitus with cardiovascular disease. Recent studies have suggested that increased MUA is an independent risk factor for vascular injury, and that it can be improved by treating primary diseases such as diabetes and hypertension.

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